Clinical Significance of an Alloantibody against the Kell Blood Group Glycoprotein
نویسندگان
چکیده
منابع مشابه
Study of Kell blood group genotype in alloimmiunized thalassemia patients
Abstract Background and Objectives Alloimmunization is the most serious problem in thalassemia patients and Anti-K is the most prevalent antibody in these patients. So accurate identification of this antigen can significantly decrease the rate of alloimmunization. Serological phenotyping is usually not reliable in multi-transfused patients. Molecular genotyping can overcome limitations of hema...
متن کاملInactivation of Kell blood group antigens by 2-aminoethylisothiouronium bromide.
Human red cells incubated with a solution containing 6% 2-aminoethylisothiouronium bromide (AET) lose activity of antigens that are part of, or related to, the Kell blood group system. However, Kx antigen is not inactivated. Studies on a wide range of other blood-group antigens show no other evidence of changes and AET appears to react specifically with red-cell membrane structures that have Ke...
متن کاملExpression of Kell blood group protein in nonerythroid tissues.
The Kell blood group protein is a zinc endopeptidase that yields endothelin-3, a potent bioactive peptide, by cleavage of big endothelin-3, a larger intermediate precursor. On red cells, Kell protein is linked by a single disulfide bond to XK, a protein that traverses the membrane 10 times and whose absence, as occurs in the McLeod phenotype, is associated with a set of clinical symptoms that i...
متن کاملA Case Report of Blood Group Discrepancy because of Anti A1 with Clinical Significance and Anti C
Abstract Background and objectives: ABO phenotyping is one of the essential tests in Immunohematology. Incompatible blood group transfusion leads to acute hemolysis reactions and other serious complications. Anti A1 is a cold Antibody with no clinical significance, but if it is reacted at 37˚c can be clinically significant, which will be happened rarely. At the present, we report a Case with a...
متن کاملPrevalence of Rh, Duffy, Kell, Kidd & MNSs blood group antigens in the Indian blood donor population
BACKGROUND & OBJECTIVES Little data are available regarding the frequencies of the blood group antigens other than ABO and RhD in the Indian population. Knowledge of the antigen frequencies is important to assess risk of antibody formation and to guide the probability of finding antigen-negative donor blood, which is especially useful when blood is required for a patient who has multiple red ce...
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ژورنال
عنوان ژورنال: Transfusion Medicine and Hemotherapy
سال: 2016
ISSN: 1660-3796,1660-3818
DOI: 10.1159/000448381